In general, acute and chronic cholecystitis, the pathogenelis is still not completely understood, seems to be related to four factors, obstruction, ischemia, chemical injury and bacterial due to chiefly biliary stone3 (90-95%), and serous systemic disorders, major injuries (trauma and operation), congenital abnormalities and other bad physical conditions3).
Above all the presense of organisms are responsible nit noly for the development of acute cholecystitis but also for the postoperative complications and mortalitys).
About 5 per cent (about 20 per cent in the United States)1), of surgical patient have been entered in this hospital for surgery of the biiiary tract because of acute and chronic cholecystitis.
In spite of that microorganisms in the biliary tract has recently not been st·udied in this country as well as other countries6).
The purpose of this investigation was to asses the incidence of organisms from the gallbladder bile of the patients with acute and chronic cholecystitis by utilifation of standardized methods of aerobic and anaerobic cultures.
Seventy eight consecutive patients with acute and chronic cholecystitis underwent oholecrstectorny during the two years and nine months between january 1981 and september 1983 were studied and also correlate the presence of bacteria cultured from gallbladder bile with leukocytes and several items of important liver function test. Ten consecutive with other diseases has been utilized as control group.
The results are summarised as follows.
1. Of these 85 patients, 42 pstents (54%) are female and 35 patients (45) are mals.
2. Reference to the table reveals that 6 of the 47 galltladder bile, or 12.8 per cent, were cultured annerobic organisms and 61 of the 78 galltlader bile, or 78.2 per cent were cultured aerobi-cally.
3. Of 10 gallbladder bile. control group, one had Positive culture which revealed Elcherichia coli .
4. The organisms obtained from annfrobic cultures were two cases of Blfteroides fragilis(33.3%), two cases of fusobactrium symbiosum a Bacteroides asacchlrolrticus and a Clostrium clostridiforme (16.7%), respectively.
5. The oganisms obtained from aerobic cultures were 32 cases (45.1%) of Escherihia coli, 19cases (26.8%) of Klebsiella species, 6 cases (8.5%) of En:erobacter species, 5 case3 (7.1%) of Proteus species, 3 cases (4.2%) of Citrobacter species, 2 cases (2.8%) of Salmonella typhi and the others were one of Providencia rritgeri, Aeromonas hydrophilia, Acinetobacter calcoaceticus.Staphl´lococcus aureus, refpectively,
6. The mean value of leukffrtes of strobic group was 12.451/mm3 obvious differents compared to control group which Las atatistically significant with a p<0.05.
7. Both mean value of SGPT, SGPT and albumin of anterobic group were P<0.05 respectively ,and SGOT and albumin of aerobic group were a p<0.01, respectively ana total bilirubin was a P＜0.05 those were statistically significant value.
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